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These situations are extremely rare; patients who have a history of contrast allergy or renal insufficiency, or those who are taking blood thinners like coumadin can still undergo UFE, but certain measures have to be taken. In patients with infection of the uterus, ovaries or genital organs, UFE can be done after the infection is completely treated. In patients with an intrauterine contraceptive device, it is preferable to get it removed before UFE. In patients who have been taking GnRH agonists, these drugs must be stopped at least three months before UFE since they may reduce the size of the feeding arteries and prevent the embolic particles to go deep into the fibroids.